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Cagrilintide and the combination drug CagriSema are investigational treatments currently undergoing regulatory review
This potency has fueled rapid demand
The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]
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doi: 10.1007/s13679-024-00592-x, 28
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